A drug may be defined as any chemical that affects biological processes. Early pharmacologists studied natural substances, mainly plant extracts such as morphine from the opium poppy, quinine from the bark of the cinchona tree and digitalis from Foxglove. Later in the 19th century pharmacology developed as a biomedical science that applied the principles of scientific experimentation to therapeutic context. Today, the Molelcular and Biochemical Pharmacology group at the University of Arizona use methods of biochemistry, molecular biology, structural biology, cell biology, and cell physiology to define the mechanisms of drug action and how drugs influence the organism by studies on intact animals, organs, cells, sub-cellular compartments and individual protein molecules.
At present, more than genes are listed as potentially contributory to hypertension. There is a plethora of sequelae that result from uncontrolled hypertension, and none of them is good: cardiovascular problems e. Many biochemical processes are affected by hypertension; abnormalities or dysregulation of many biochemical pathways can contribute to the development of hypertension.
This thematic minireview series will explore several novel aspects of the biochemistry of hypertension and how this biochemistry interfaces at the physiological and clinical levels.
The first minireview, by Joseph Hill of the University of Texas Southwestern Medical Center's department of internal medicine and division of cardiology, explores the role of cardiac cell autophagy in hypertension. The mechanisms of autophagy as related to hypertension-induced cardiac remodeling, ultimately contributing to ischemic heart disease and failure, will be examined.
Curt Sigmund , a professor of medicine and molecular physiology and biophysics at the University of Iowa and director of the Center on the Functional Genomics of Hypertension at the university's Carver College of Medicine, summarizes the role that peroxisome proliferator-activated receptor gamma PPARy transcription factor plays in the endothelium and vascular smooth-muscle cells using genetically altered mouse models of hypertension.
The third article in this series is by Rebecca Hughey and Tom Kleyman , both of the renal-electrolyte division at the University of Pittsburgh School of Medicine. James Bubien , associate professor of physiology and biophysics at the University of Alabama at Birmingham, continues this theme by summarizing evidence that the hormonal stimulation of ENaC by aldosterone and insulin, two hormones elevated in obese individuals with therapy-resistant hypertension, may contribute to the hypertension that accompanies obesity.
He also proposes a different paradigm in which serum potassium level plays an important, if not critical role, in hypertension.
The fifth and final minireview of this series is by John Hall , associate vice chancellor for research at the University of Mississippi Medical Center and editor-in-chief of the journal Hypertension. The focus of his article is also obesity and hypertension. If you do not already have an account you will need to register here.
Biochemistry and Molecular Medicine BSc - University of Nottingham
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While medicinal chemistry is a topic of complimentary interest, manuscripts in this area must contain sufficient biological data to characterize pharmacologically the compounds reported. Submissions describing work focused predominately on chemical synthesis and molecular modeling will not be considered for review.
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